单细胞数据推理对模型构造的 (不) 依赖性
Catherine M Grgicak1, Klaas Slooten2, Robert G Cowell3
1Program in Forensic Sciences, Department of Chemistry, Rutgers University, Camden, NJ 08102, USA; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ 08102, USA.
Forensic science international. Genetics
|January 16, 2025
概括
这项研究比较了三种概率模型,用于在法医中解释单细胞电表图 (scEPGs). 所有模型都有效地解决了假设,证据权重 (WoEs) 显示了模型之间强烈的一致性,表明了强大的法医适用性.
科学领域:
- 法医科学 法医科学 法医科学
- 遗传学 是一个遗传学.
- 生物统计学 生物统计学
背景情况:
- 单细胞分析提供了先进的法医见解,但解释模型可以产生不同的证据权重 (WoEs).
- 了解模型的差异对于一致的法医证据审查至关重要.
研究的目的:
- 评估和比较由三个不同的概率模型为单细胞电表图 (scEPGs) 生成的证据权重 (WoEs).
- 在不同模型中识别法医单细胞数据解释不一致的来源.
主要方法:
- 在996个scEPG上对三个模型 (EESCIt,TD,DCM) 的性能测试,使用真假贡献者测试.
- 对每个模型的201,192个结果进行分析,以评估假设解析和WoE校准.
- 使用类内相关的对分析来评估scEPG WoEs的模型间协议.
主要成果:
- 这三种模型都有效地解决了scEPG的假设.
- 证据权重 (WoEs) 在模型中显示出强烈的一致性,类内相关性≥0.99997.7.
- 模型校准通常是准确的,在特定的scEPG中,与极端口吃信号相关的罕见差异.
结论:
- 评估的模型 (EESCIt,TD,DCM) 适当地指出了scEPG在相关范围内的WoEs.
- 调查结果支持单细胞数据解释在这些模型中的合法性.
- 拟议的解释性适应可以改善预测罕见事件的差异.
相关概念视频
Mechanistic Models: Compartment Models in Individual and Population Analysis
26
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
26
Introduction to Test of Independence
2.2K
In statistics, the term independence means that one can directly obtain the probability of any event involving both variables by multiplying their individual probabilities. Tests of independence are chi-square tests involving the use of a contingency table of observed (data) values.
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
2.2K
Hypothesis Test for Test of Independence
3.5K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
H0: The two variables (factors)...
3.5K
Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Biostatistics: Overview
219
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
Discrete variables are...
219
One-Way ANOVA: Equal Sample Sizes
3.2K
One-Way ANOVA can be performed on three or more samples with equal or unequal sample sizes. When one-way ANOVA is performed on two datasets with samples of equal sizes, it can be easily observed that the computed F statistic is highly sensitive to the sample mean.
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...
3.2K


