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自动基础剂量规划,用于在总骨髓辐射中强大的场接点

Nicola Lambri¹, Damiano Dei¹, Ricardo Coimbra Brioso²

¹IRCCS Humanitas Research Hospital, Radiotherapy and Radiosurgery Department, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|January 16, 2025

概括

一种新的基剂量规划方法显著改善了总骨髓辐射 (TMI/TMLI) 领域结点覆盖率,并减少了健康组织热点. 这种自动化方法增强了放射治疗计划,以挑战全身治疗.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
放射治疗规划放射治疗规划

背景情况:

总骨髓照射 (TMI/TMLI) 需要全身照射,由于临床限制,通常需要分期计划.
在分割TMI/TMLI计划的交叉点实现充足的目标覆盖面是具有挑战性的,需要仔细的现场交叉点设计.
之前的工作引入了一个自动工具 (AT),用于创建和优化TMI/TMLI现场结.

研究的目的:

通过开发自动基础剂量规划方法来增强TMI/TMLI的现有自动工具 (AT).
为了提高整个骨髓照射中场路口优化的准确性和效率.

主要方法:

10名患者接受了TMI/TMLI,使用了三种计划方法:手动,原始AT和新的基本剂量AT.
根据剂量统计数据 (D98%,Dmean,D2%) 评估治疗计划,用于计划目标体积在结点 (PTV_J),没有结点的PTV (PTVNoJ) 和健康组织.

主要成果:

与手动方法相比,基本剂量规划方法显著改善了PTV_J覆盖率 (较高的D98%,较低的D2%).
根据基本剂量方法,健康组织中的热点显著减少.
对于PTVNoJ的目标覆盖范围在所有方法中保持一致,表明可比的整体目标覆盖范围.

结论:

自动基础剂量规划有效地优化了TMI/TMLI的现场交叉点,提高了目标覆盖率并减少了正常组织的毒性.
自动化规划工具为复杂且可能容易出错的放射治疗程序 (如TMI/TMLI) 提供了有价值的解决方案.

关键词:

自动化自动化自动化自动化自动化现场交叉点的交叉点是什么?放射疗法是一种放射治疗.总骨髓辐射 (TMI) 的时间总的骨髓淋巴结辐射 (TMLI)卷度调制光弧疗法 (VMAT) 是一种光弧疗法.

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