聚髓炎和皮肤肌炎患者患动脉样硬化相关疾病的风险:一项基于人口的大规模研究
Lior Fisher1, Niv Ben-Shabat1, Omer Gendelman1
1Department of Internal Medicine B & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Atherosclerosis
|January 16, 2025
概括
多肌肉炎 (PM) 和皮肤肌肉炎 (DM) 会增加心脏病发作和中风的风险. 患有PM/DM和APLA相关抗体的患者面临更高的动脉样硬化心血管疾病 (ASCVD) 率.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 系统性自身免疫性疾病,包括多聚肌炎 (PM) 和皮肤肌炎 (DM),与增加的动脉样硬化心血管疾病 (ASCVD) 有关.
- 炎症在动脉动脉生成中起着至关重要的作用,但PM/DM和ASCVD事件之间的特定关联仍未得到充分研究.
研究的目的:
- 调查PM/DM和ASCVD事件之间的关联.
- 检查疾病修饰剂,自身抗体和传统心血管疾病 (CVD) 风险因素的发病率,死亡率和相互作用.
主要方法:
- 进行了一项回顾性队列研究,使用来自Clalit Health Services (CHS) 的电子健康记录.
- 在2000-2016年间诊断的1899名PM/DM患者与7676名健康对照 (1:5比) 根据年龄和性别进行了匹配.
- 在使用单变量和多变量模型的组之间比较ASCVD发病率,并根据基线心血管疾病风险因素进行调整.
主要成果:
- 与对照组相比,PM/DM患者的缺血性心脏病 (IHD) (HR 1.61) 和脑血管事故 (CVA) (HR 2.45) 发生率显著更高.
- 在PM/DM组 (HR 1.75) 中,ASCVD的总体风险较高.
- 对APLA相关抗体阳性PM/DM患者的ASCVD风险显著增加 (OR 2.33).
结论:
- 多髓炎和皮肤肌炎与IHD和CVA的风险增加有关.
- 患有APLA相关抗体的PM/DM患者表现出特别高的ASCVD率.
- 对于PM/DM患者来说,需要提高对心血管,神经和血管结果的认识和监测.
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