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2-乙基二酸会诱导小的肺氧化应激和烧亡

Yiming Sun¹, Ruili Zhang¹, Jiali Li¹

¹College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Harbin 150030, China.

The Science of the total environment

|January 16, 2025

概括

2-乙烯二酸 (EHDPHP) 通过诱导氧化应激和激活细胞热,导致小的肺损伤. 这些发现揭示了EHDPHP的EHDPHP.

科学领域:

环境毒理学环境毒理学
有机化合物毒性有机化合物毒性
禽类的健康禽类的健康

背景情况:

2-乙烯二酸 (EHDPHP) 是一种常见的阻燃剂和可塑化剂,具有环境持久性.
它的毒理作用,特别是对鸟类肺组织的毒理作用,尚不清楚.
由于环境暴露,家禽肺部是EHDPHP的潜在目标.

研究的目的:

为了研究EHDPHP对小肺部的毒性影响.
阐明潜在的机制,包括氧化应激和热.
提供数据,以安全使用和污染控制EHDPHP.

主要方法:

小的口腔中含有不同度的EHDPHP.
分析了肺部组织,以检测其组织病理学和超病理学变化.
生物化学测定和分子技术 (qRT-PCR,西斑,ELISA) 评估了损伤标志物,氧化应激,热和炎症因素.

主要成果:

暴露于EHDPHP导致了剂量依赖的肺损伤,包括形态变化和升高的LDH.
抗氧化酶活性 (GSH-Px,SOD) 降低,而脂质过氧化 (MDA) 增加,表明氧化应激.
细胞质炎症 (NLRP3,ASC,NF-κB,Pro-Caspase-1,IL-18,IL-1β) 和炎症 (IL-6,TNF-α) 显著上调.

结论:

在的肺部中,EHDPHP会引发显著的氧化应激和损伤.
细胞火灭亡途径被激活,并导致EHDPHP诱导的炎症和肺损伤.
这项研究为家禽中EHDPHP毒性机制提供了新的见解.

关键词:

一个漂亮的小.欧盟人权与公众健康计划肺组织的肺组织.氧化应激是一种氧化应激.热性灭症 (Pyroptosis) 是一种

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