肠道-大脑轴微生物群可以逆转人类的神经退行性疾病吗?
Xingxing Yuan1, Serge Yannick Ouedraogo2, Modou Lamin Jammeh3
1First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China; Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150006, China.
Ageing research reviews
|January 16, 2025
概括
肠道微生物群的健康影响大脑功能和神经退行性疾病 (NDD). 本综述探讨了肠-大脑轴疗法,强调了对NDD的非药物干预.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在健康和疾病中起着至关重要的作用.
- 失生症或微生物多样性减少与神经退行性疾病 (NDD) 有关.
- 肠道微生物群-大脑轴是治疗干预的关键途径.
研究的目的:
- 审查基于肠道微生物群的治疗策略对NDDs的临床意义.
- 确定肠道微生物群-大脑轴的研究缺口和前景.
- 探索扭转NDD的潜在干预措施.
主要方法:
- 在PubMed数据库中使用关键词"肠道微生物群"和"神经退行性疾病"进行文献搜索.
- 包括过去5年内以英语出版的研究,包括评论,元分析和RCT.
- 分析的重点是了解肠道微生物群-大脑轴,研究差距和治疗前景.
主要成果:
- 肠道微生物群干预表明通过肠-大脑轴对各种疾病具有治疗潜力.
- 非药物干预似乎比药物疗法更有效地逆转NDD.
- 早期发现和预防策略对于管理NDD至关重要.
结论:
- 以肠道为导向的治疗方法在治疗神经疾病方面具有显著的前景.
- 需要进一步的研究,包括神经成像,以确定临床意义.
- 需要采用整体方法来解决肠道微生物群-大脑轴的结构和功能变化.
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