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替代生长激素治疗对中国儿童近视控制的影响

Yi Lu¹, Jiamin Xie¹, Lele Cheng²

¹Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

|January 16, 2025

概括

重组人体生长激素 (rhGH) 疗法加速近视儿童的眼睛生长,即使有近视控制干预措施. 对于这些患者,建议采用双疗法近视控制策略.

科学领域:

儿科内分泌学儿科内分泌学
眼科医生眼科眼科
近视研究近视研究

背景情况:

近视是一种日益严重的全球健康问题,特别是在儿童中.
重组人体生长激素 (rhGH) 疗法用于生长缺陷,但可能会影响眼部发育.
了解rhGH和近视进展之间的关系对于有效的管理至关重要.

研究的目的:

调查rhGH治疗与儿童近视进展之间的相关性.
为了评估不同近视控制策略在RhGH治疗近视儿童的有效性.

主要方法:

追溯性研究比较27名近视儿童接受RhGH治疗与57名近视对照.
使用IOLMaster和自折器测量轴长 (AL) 和折射.
在RhGH治疗前后对AL变化的分析以及对近视控制策略的比较.

主要成果:

与对照组 (0.18 mm/年) 相比,rhGH组的AL变化显著增加 (0.29 mm/年).
在rhGH治疗期间,轴延长增加,停止后减少.
更长的rhGH持续时间和更短的近视控制持续时间与更快的轴延长有关.
双疗法近视控制在缓解过度轴延长方面比单疗法更有效.

结论:

尽管正在进行近视控制,但rhGH疗法在近视儿童中加速了轴延长.
对于接受rhGH治疗的儿童,密切的眼科监测至关重要.
双疗法近视控制策略可以在这个人群中提供更好的保护,防止近视的加速进展.

关键词:

轴长度轴长度轴长度控制近视,控制近视.近视的进展近视的进展重组的人体生长激素重组的人体生长激素

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