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The Parathyroid Glands00:59

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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第2章:一次性副甲状腺功能障碍症:诊断

Benjamin Bouillet1, Jean-Philippe Bertocchio2, Claire Nominé-Criqui3

  • 1Department of Endocrinology, Diabetology and Nutrition, CHU de Dijon, 21000 Dijon, France; Inserm Research Center U1231, Padys Team, 21000 Dijon, France; University of Burgundy, 21000 Dijon, France.

Annales d'endocrinologie
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PubMed
概括

初级甲状腺功能障碍症往往无症状,需要对器官损伤进行查. 诊断依赖于生物标志物,如血液中的和副甲状腺激素水平,特别是在非典型的病例中.

关键词:
没有症状的无症状.生物诊断 生物诊断是一种生物学诊断.过高血症的情况.骨关节的参与主要的副甲状腺功能障碍症.患有脏干扰的情况

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科学领域:

  • 内分泌学 在内分泌学.
  • 生物化学 生物化学

背景情况:

  • 由于常规血液检查,在无症状个体中越来越多地诊断出原发性副甲状腺症 (PHPT).
  • PHPT的经典临床症状涉及骨,脏和肌肉,在甲状腺外科手术后可能会逆转.
  • 影响心血管,消化和神经心理系统的非经典表现也被认可,手术后的可逆性不确定.

研究的目的:

  • 概述初级甲状腺功能障碍症的诊断策略,重点是识别无症状患者的目标器官损伤.
  • 根据生物标记,区分典型和非典型的PHPT形式.
  • 突出非典型的PHPT演示的诊断工具.

主要方法:

  • 系统的血测定用于查.
  • 评估经典 (骨,脏,肌肉) 和非经典 (心血管,消化,神经心理) 症状.
  • 生物诊断基于甲状腺前激素 (PTH) 水平相对于血中的.
  • 在典型的PHPT中评估高血症,升高的PTH和尿/分泌率.
  • 对非典型形式的诊断方法,包括正常的PTH与高血症或正常的血症与升高的PTH,考虑到像维生素D缺乏症这样的条件.
  • 使用口服负荷测试和非典型病例的Pro-FHH得分.

主要成果:

  • 诊断PHPT越来越依赖于检测无症状患者的器官损伤.
  • 经典症状在手术后是可逆的,而非经典症状的可逆性是不确定的.
  • 典型的PHPT的特征是高血症,高PTH和增加的尿.
  • 非典型的形式带来诊断挑战,需要特殊的测试,如口服负荷测试和Pro-FHH得分.

结论:

  • 对目标器官损伤的系统查和评估对于诊断无症状原发性副甲状腺炎至关重要.
  • 生物标志物,特别是和PTH之间的关系,是诊断的关键.
  • 非典型的表现需要专门的诊断工具,以确保PHPT的准确识别和管理.