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血D-二次体变化和临床价值在急性下肢深静脉血栓症治疗以导管导向的血栓溶解

Jixu Wang¹, Yide Zheng², Yongzhong Yu²

¹Department of Vascular Surgery, Chenzhou First People's Hospital and the First Affiliated Hospital of Xiangnan University, Chenzhou, Hunan Province, China; Department of Medical lmaging Laboratory and Rehabilitation, Xiangnan University, Chenzhou, Hunan Province, China; Department of Interventional Vascular Surgery, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, Hunan Province, China.

Journal of vascular surgery. Venous and lymphatic disorders

|January 16, 2025

概括

血D-二聚物水平可以表明导管导向血栓溶解 (CDT) 对急性深静脉血栓 (DVT) 的有效性. 在CDT期间监测D-二聚体有助于评估下肢DVT患者的血栓清除和治疗成功.

科学领域:

血管医学血管医学
干预性放射学干预性放射学
血液学血液学血液学

背景情况:

急性下肢深静脉血栓形成 (DVT) 存在重大风险.
导导管血栓溶解 (CDT) 是对DVT的一种治疗选择.
监测治疗疗效对于患者的治疗结果至关重要.

研究的目的:

为了研究在CDT期间急性下肢DVT的血D-二聚合物水平变化.
分析D-二次元水平的成像结果和临床影响.
评估D-二聚合物水平与血栓清除之间的相关性.

主要方法:

对62名接受CDT治疗急性下肢DVT的患者的回顾性分析.
在CDT之前,期间和之后,对血D-二聚合物水平的连续测量.
定期下肢静脉扫描以评估血栓清除率和溶解.
包括相关性和ROC曲线构造在内的统计分析,以评估D-二分体的诊断性能.

主要成果:

血D-二聚合物水平最初增加,然后在CDT期间下降,显示出与血栓溶解疗效的强烈正相关性 (r=0.809).
接收器操作特征曲线显示了D-二次体的高诊断性能 (AUC=0.95).
对D-二元体的最佳切断值为9.935 mg/L表明高灵敏度 (93.2%) 和特异性 (95.4%) 在评估血栓溶解疗效.

结论:

血D-二聚合物度是评估急性下肢DVT期间CDT中血栓溶解功效的可靠指标.
D-二次元监测可以帮助实时评估治疗反应.
这一发现支持使用D-二次体作为生物标志物来管理CDT的DVT.

关键词:

下肢急性深静脉血栓形成的情况.用导管导向的血栓溶解.这是一种等离子体D-二分体.血栓溶解速度是多少血栓溶解速度是多少

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