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系统性红斑狼中的甲状腺激素:疾病进展的催化剂?
Qiu-Rui Li1, Lin-Lin Li2, Yang Dong3
1People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
The American journal of the medical sciences
|January 16, 2025
概括
甲状腺功能显著影响全身性红斑狼 (SLE) 的严重程度. 在SLE患者的甲状腺功能低下与疾病恶化和更高的器官损伤风险相关,低FT3和FT4表明炎进展.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病.
- 甲状腺功能障碍是自身免疫性疾病中常见的并发症.
- 甲状腺状况和SLE活动之间的相互作用需要进一步阐明.
研究的目的:
- 调查不同甲状腺功能状态对SLE患者临床和实验室指标的影响.
- 评估甲状腺激素与疾病活动,脏干扰和SLE患者的整体疾病严重程度之间的关系.
主要方法:
- 对258名SLE患者的回顾性分析.
- 基于甲状腺功能 (乙甲状腺,甲状腺功能低下,甲状腺功能过高),脏参与和SLE疾病活动指数2000 (SLEDAI-2K) 的分层.
- 使用接收器操作特征 (ROC) 曲线评估甲状腺激素预测值.
主要成果:
- 在258名SLE患者中,有117名患有甲状腺激素异常 (112名甲状腺功能低下,5名甲状腺功能过高).
- 血清FT3和FT4水平与总蛋白质和白蛋白正相关,与SLEDAI-2K和24小时尿蛋白 (24hUP) 负相关.
- 患有脏干扰的SLE患者表现出较低的FT3/FT4和更高的TSH水平;随着疾病活动的增加,FT3水平下降. ROC分析表明FT3,FT4和TSH的预测值.
结论:
- 甲状腺功能与SLE严重程度有显著的相关性.
- 在SLE患者的甲状腺功能低下症与更明显的疾病表现和增加器官损伤风险有关.
- 在SLE患者中,低FT3和FT4水平预测了患狼性炎的更高倾向.
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