干燥纳米乳液配方的制备方法 通过电制备干燥纳米乳液配方
Josip Ljubica1, Črt Dragar2, Tanja Potrč2
1University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10000 Zagreb, Croatia.
概括
电将液态纳米乳液转化为固体纳米纤维,用于治疗干眼疾病. 这种新的方法增强了眼睛表面的药物保留,提供了一个有前途的新疗法策略.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 干眼疾病涉及膜不稳定性.
- 目前的纳米乳液处理方法限制了眼睛表面的保留.
- 开发稳定,长效的眼部药物输送系统至关重要.
研究的目的:
- 使用电旋转,开发出一种固体的眼科制剂.
- 在纳米乳液中加载 loteprednol 和 etabonate 抗炎药物.
- 为了改善干眼疾病的眼表面药物保留.
主要方法:
- 使用水友性聚合物 (聚乙烯氧化物,Poloxamer 188,Soluplus®) 的油在水纳米乳液的电.
- 将洛特普雷德诺乙酸盐纳入纳米乳液中,其油与表面活性剂的比例各不相同.
- 使用3D HCE-T模型进行纳米纤维分散,滴滴大小,质性质和生物相容性的表征.
主要成果:
- 干燥的纳米乳液形成了迅速分散的纳米纤维.
- 纳米纤维分散产生了纳米尺寸的水滴,与最初的纳米乳液相比.
- 分散的纳米纤维表现出弹性行为,在眼睛表面形成一个微弱的凝.
- 在人类角膜表皮模型中证实了生物相容性.
结论:
- 电旋成功地从纳米乳液中制造出一种固体,迅速分散的眼睛制剂.
- 由此产生的纳米纤维增强了眼睛表面的保留和药物输送.
- 这种创新的固体纳米乳液配方显示出治疗干眼疾病的潜力.
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