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Updated: Jun 2, 2025

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

Published on: November 11, 2018

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机械传导中的蛋白质先化:对疾病和治疗的影响

Heng Chen1, Jian Yang2, Qingzhen Yang3

  • 1Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China.

Trends in pharmacological sciences
|January 16, 2025
PubMed
概括

蛋白质化是细胞如何感知机械力的关键,影响细胞行为和疾病. 这篇评论探讨了先化.

关键词:
生物物理特征 生物物理特征机械生物学 机械生物学机械传导 机械传导化前化是什么意思

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Protein Kinases and Phosphatases

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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