狼病活动状态和Foxp3基因多态性
Hanaa I Abd El-Hady1, Enas I Abdelhady2, Mai A Kamel1
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
The Egyptian journal of immunology
|January 17, 2025
概括
这是Foxp3基因.
科学领域:
- 免疫遗传学 免疫遗传学
- 类风湿病学 类风湿病学
- 分子生物学分子生物学
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,具有多样化的临床表现.
- 叉头盒蛋白3 (Foxp3) 是调节T (T-reg) 细胞功能的关键转录因子.
- 免疫相关基因中的遗传变异,特别是单核酸多态 (SNP),可以影响自身免疫性疾病的易感性.
研究的目的:
- 调查功能性Foxp3-3279 (rs3761548 C/A) 基因多态性与患SLE的风险之间的关联.
- 评估这种多态性和SLE患者的疾病活动状态之间的关系,包括狼性炎.
主要方法:
- 采用了病例控制研究设计,包括被诊断为SLE患者和对照组.
- 疾病活动使用系统性狼发疹性疾病活动评分 (SLE-DAS) 来量化疾病活动.
- 对Foxp3-3279 (rs3761548 C/A) 多态的基因定型使用聚合酶连锁反应限制片段长度多态 (PCR-RFLP) 分析进行.
主要成果:
- 福克斯p3-3279多态的AA和AC基因型与SLE风险增加显著相关 (分别为7.25倍和2.88倍).
- 该A基因组显示,SLE发病风险增加了3.12倍.
- 该AA基因型与中度至重度的SLE疾病活动和狼性炎风险增加33.6倍密切相关.
结论:
- 福克斯p3 -3279 (rs3761548 C/A) 基因多态性与发展SLE的风险和狼性炎的发生显著相关.
- 这种基因变异与SLE疾病活动的联系强调了Foxp3基因在SLE病变和临床表现中的作用.
- 识别这种SNP可能会为SLE管理提供个性化治疗策略的见解.
更多相关视频
08:20In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
Published on: December 30, 2016
20.2K
11:06Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
Published on: September 20, 2017
6.1K
相关概念视频
01:33Pleiotropy
39.6K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.6K
01:24T Cell Types and Functions
946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
01:30General Transcription Factors
5.2K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.2K