青春期时间作为表观遗传衰老和年轻成人死亡风险的预测指标
Marlon Goering1, Malcolm Barker-Kamps1, Amit Patki2
1Department of Psychology, University of Alabama at Birmingham.
Developmental psychology
|January 17, 2025
概括
早期青春期与更高的表观遗传衰老和成年期死亡风险有关. 这些影响在不同的年轻人中观察到,在表观遗传标记中注意到一些性别特异性差异.
科学领域:
- 青少年健康 青少年健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 长寿研究研究 长寿研究
背景情况:
- 早期青春期的时间是已知的不良成年健康结果的风险因素.
- 通过加速细胞衰老和死亡风险,DNA甲基化变化可能会调解这些效应.
- 关于青春期定时与成年后表观遗传标记的关联,特别是在多样化的群体中,考虑到性别差异,研究有限.
研究的目的:
- 研究早期青春期时间 (感知和表型) 和表观遗传衰老标志物 (GrimAge,DunedinPace of Aging Calculated from the Epigenome,PhenoAge) 与年轻成人死亡风险之间的纵向关联.
- 检查黑人青年中这些关联中的性别差异.
主要方法:
- 长度研究350个人 (80%黑人,58%女性) 从青春期 (13岁) 到年轻成人 (27岁).
- 通过同行比较和年龄调整的坦纳分数来评估青春期时间.
- 基因表观衰老和死亡风险是使用已建立的基因表观时钟 (GrimAge, DunedinPace of Aging Calculated from the Epigenome, PhenoAge) 来衡量的.
- 统计调整包括吸烟,BMI,收入,早期生活压力,种族/种族,性别和父母身份在内的共变量.
主要成果:
- 早期感知和表型性青春期时间预测了更高的表观遗传死亡风险.
- 早期的表型性青春期时间预测加速的衰老速度,从表观基因组计算.
- 既感知和表型的早期青春期时间与加速的灰色年龄相关.
- 时间外的表型青春期时间显示,只有男性的PhenOAge加速.
- 感知时间外的青春期时间出乎意料地与较低的PhenoAge加速有关.
结论:
- 早期青春期的时间与加速衰老的表观遗传标记和不同年轻人的死亡风险增加有关.
- 研究结果强调了表观遗传衰老在调解早期青春期的长期健康后果方面的作用.
- 年加速的非线性效应和性别差异强调了青春期时间对衰老轨迹的影响的复杂性.
相关概念视频
Signs of Puberty
231
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
231
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Aging
36
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
36
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Gene-Environment Interactions
248
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
248
Menopause
129
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
129


