在中国发现了一种新型的HIV-1第二代循环复合形式 (CRF117_0107)
Xiaorui Wang1,2, Bo Zhu2,3, Hanping Li2
1Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Key Laboratory for the Prevention and Control of Emerging Infectious Diseases and Biosafety, Shandong University, Jinan, China.
AIDS research and human retroviruses
|January 17, 2025
概括
一种新的HIV-1第二代复合菌株CRF117_0107在中国出现,它结合了CRF01_AE和CRF07_BC的元素. 这一发现突显了这种重组物的频率日益增加,并强调了对与男性发生性关系的男性 (MSM) 群体进行监测的必要性.
科学领域:
- 病毒学 病毒学
- 分子流行病学分子流行病学
- 公共卫生 公共卫生
背景情况:
- 主要的HIV-1菌株CRF01_AE和CRF07_BC在中国的同时流通.
- 来自CRF01_AE和CRF07_BC的HIV第二代复合菌株 (SGR) 的出现.
- 需要描述新的复合形式,以了解艾滋病毒的演变.
研究的目的:
- 描述一种新型的HIV-1第二代复合形式 (CRF117_0107).
- 分析CRF117_0107.7的遗传起源和重组模式.
- 评估CRF117_0107对中国艾滋病毒流行病学的影响.
主要方法:
- 从受感染个体中扩大和测序几乎全长的HIV-1基因组 (NFLG).
- 遗传学分析以确定遗传集群和关系.
- 重组分析以确定基因组段的断点和父系起源.
主要成果:
- 一种新的HIV-1 SGR菌株的鉴定和特征,CRF117_0107.
- 遗传学分析证实CRF117_0107序列形成了一个独特的单种群.
- 重组分析显示CRF117_0107包括CRF01_AE和CRF07_BC的部分.
结论:
- CRF117_0107代表了中国的新一代HIV-1第二代复合菌株.
- CRF117_0107的出现表明,从CRF01_AE和CRF07_BC中增加了SGR菌株的产生.
- 在像MSM这样的高风险人群中监测HIV-1第二代CRF对于了解HIV流行病动态至关重要.
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