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Updated: Jun 2, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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发现了与无七之子2 (SOS2) 结合的小分子

Krzysztof M Zak1, Alex G Waterson2, Leonhard Geist1

  • 1Boehringer Ingelheim RCV GmbH & Co. KG, A-1121 Vienna, Austria.

Journal of medicinal chemistry
|January 17, 2025
PubMed
概括

研究人员发现了新的基于quinazoline的化合物,其向SOS2蛋白,SOS2蛋白是RAS驱动癌症的关键参与者. 这一发现为通过抑制SOS2活性来治疗恶性瘤提供了潜在的治疗策略.

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