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Updated: Jun 2, 2025

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
06:56

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

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预突触功能受损对甘氨酸受体自身抗体的病理有显著的贡献

Anna-Lena Wiessler1, Fang Zheng2, Christian Werner3

  • 1Institute for Clinical Neurobiology, University Hospital, Julius-Maximilians-University of Würzburg, Germany.

Neurology(R) neuroimmunology & neuroinflammation
|January 17, 2025
PubMed
概括

针对甘氨酸受体 (GlyRs) 的自身抗体可以影响前突触功能,影响神经系统疾病,如刚性人群综合征 (SPS) 和渐进性脑筋炎与刚性和肌细胞结合 (PERM). 这项研究揭示了GlyRα2作为一个关键的前突触点,解释了患者的各种症状.

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