在患有多发性硬化症的患者免疫乱后,肠道微生物组与宿主关系的改变
Vinod K Gupta1, Guneet S Janda2, Heather K Pump3
1Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
Neurology(R) neuroimmunology & neuroinflammation
|January 17, 2025
概括
新诊断的多发性硬化症 (MS) 患者表现出改变的肠道细菌-IgA结合. B细胞枯竭疗法部分恢复了这些微生物模式,突出了肠道微生物组在MS中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 肠道微生物共生体影响自身免疫力,通过微生物-IgA接口与多发性硬化症 (MS) 病理生理学的新兴联系.
- 在MS患者中观察到分泌IgA的B细胞和改变的肠道细菌-IgA结合,但宿主免疫反应,特别是B细胞枯竭,尚未得到充分研究.
研究的目的:
- 通过使用长读测序,评估在基线和B细胞枯竭后新诊断的MS患者的肠道微生物组组成.
- 通过评估微生物/免疫球蛋白A (IgA) 关系来研究宿主/微生物群相互作用.
主要方法:
- 从43名新诊断的,未经治疗的多发性硬化症患者和42名健康对照组收集的便样本.
- 19名多发性硬化症患者提供了6个月抗CD20治疗后的样本.
- 细菌流细胞测量和长时间读取的16S rRNA基因测序分析了宿主-微生物接口,免疫涂层得分比较IgA涂层与未涂层细菌.
主要成果:
- 与对照组相比,未经治疗的多发性硬化症患者显示IgA结合的便微生物群减少.
- 在总和IgA涂层分量中观察到显著的菌株级肠道细菌变化 (ASV).
- 具体的变化包括在MS中减少*Faecalibacterium prausnitzii*和增加*Monoglobus pectinyliticus*;在治疗后正常化IgA涂层的*Akkermansia muciniphila*.
结论:
- 对肠道微生物ASVs的分析揭示了MS中免疫调节引起的分类学菌株转移.
- 这些发现突出了肠道微生物群,IgA和宿主免疫系统在MS病原和治疗反应中的动态相互作用.
更多相关视频
相关概念视频
01:26Factors Affecting the Risk of Infection
11.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.3K
01:17Irritable Bowel Syndrome I: Introduction
243
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
243