在没有活跃肺部疾病的健康受试者中,通过计算机断层扫描对中央呼吸道失灵的螺旋计估计
Takafumi Shimada1, Naoya Tanabe2, Fumi Mochizuki1
1Department of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan.
通过螺旋测量测量得出的呼吸阻塞比率 (DR) 可以估计整个中央呼吸道树的计算机断层扫描 (CT) 评估的气道到肺部尺寸不匹配. 峰值呼气流量/强迫生命能力 (PEF/FVC) 螺旋计可以估计CT评估的大型肺外气道的呼吸障碍.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是指放射学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 呼吸道到肺部尺寸不匹配的失联症与肺部疾病风险有关.
- 计算机断层扫描 (CT) 评估的失眠症有助于风险估计,但涉及辐射暴露.
- 检查螺旋计指数以估计CT评估的dysanapsis对于可访问的风险评估至关重要.
研究的目的:
- 在健康个体中识别可估计CT评估的中央呼吸道失灵症的螺旋计指数.
- 为了比较不同的螺旋计指数在反映气道到肺部大小差异的有效性,在各种气道水平.
主要方法:
- 测量了螺旋计指数,包括dysanapsis比率 (DR),FEF25-75/FVC,FEV1/FVC和PEF/FVC.
- CT扫描显示了中央和肺外气道的气道到肺的大小比 (ALR14和ALR4).
- 根据ALR14或ALR4对受试者进行了分类,以确定CT评估的dysanapsis.
主要成果:
- 在男性 (0.80) 和女性 (0.78) 中,DR显示了检测最低ALR14 (整个中央气道树) 的曲线下的最高区域 (AUC).
- 在男性 (0.67) 和女性 (0.77) 中,PEF/FVC显示了检测最低ALR4 (肺外气道) 的最高AUC.
- 螺旋测量指数与CT评估的呼吸障碍相关,根据呼吸道区域的变化.
结论:
- 螺旋测量失灵症比率 (DR) 可以在整个中央气道树上估计CT评估的失灵症.
- 螺旋计指数PEF/FVC可以估计CT评估的呼吸障碍,特别是在肺外气道.
- 螺旋计提供了一种无辐射的方法来评估气道到肺的尺寸不匹配,有助于肺部疾病风险分层.
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