童年不良经历和创伤后压力对青少年大脑连接和酒精使用的影响
Mary Milo O Woodley1, Qingyu Zhao2, David B Goldston3
1Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA.
概括
儿童不良经历 (ACE) 和创伤后应激障碍 (PTSD) 症状与青少年大脑连接的改变有关. 解决PTSD可能会减少酒精使用问题并改善大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 儿童不良经历 (ACE) 与长期的心理健康问题有关.
- 创伤后应激障碍 (PTSD) 的症状可以在创伤暴露后出现.
- 青春期是大脑发育和易受物质使用影响的关键时期.
研究的目的:
- 研究ACE,PTSD症状,休息状态功能连接 (rs-FC) 和青少年的酒精使用之间的关系.
- 检查特定大脑网络内的rs-FC如何受到ACE和PTSD的影响.
- 了解改变大脑连接和使用酒精问题的关系.
主要方法:
- 利用功能磁共振成像 (fMRI) 数据来自全国青少年酒精和神经发育联盟 (NCANDA) 研究 (N=687).
- 在默认模式,突出和中间前端平行网络中分析了网络内静止状态功能连接 (rs-FC).
- 与报告的ACE相关的rs-FC模式,PTSD症状严重程度和酒精使用问题.
主要成果:
- ACE与默认模式,突出和中间前对对联网络中的 rs-FC 减少有关.
- 除了ACE外,PTSD症状的存在还导致了默认模式和中间前对对联网络内的rs-FC进一步减少.
- 较低的网络内 rs-FC 与增加的酒精使用问题有关,包括戒断症状.
结论:
- 创伤后应激障碍症状与网络内 rs-FC 减少有关,独立于ACE暴露.
- 在有ACE和PTSD史的青少年中,大脑连接的改变可能会导致酒精使用问题.
- 针对ACE青少年的PTSD症状的干预可能对减轻大脑连接性变化和降低酒精使用风险至关重要.
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