在患有状细胞病的儿科群体中,维生素D缺乏
Thiago de Souza Vilela1,2, Mauro Fisberg2,3, Gerson Ferrari4,5
1Department of Pediatrics - Division of Pediatric Hematology, Universidade Federal de São Paulo, Sao Paulo, Brazil.
Pediatric hematology and oncology
|January 17, 2025
概括
维生素D缺乏症在患有状细胞疾病的儿童中很常见,影响了近一半的研究对象. 风险因素包括年龄较小,阳光照射较少,以及秋季或冬季进行测试.
科学领域:
- 儿科血液学 儿科血液学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 状细胞疾病 (SCD) 是一种与众多并发症相关的遗传性血液疾病.
- 越来越多的人认为维生素D缺乏是儿童群体的重大健康问题.
- 儿科SCD患者的低维他明症D可能会加剧临床结果.
研究的目的:
- 确定患有SCD的儿科患者中维生素D缺乏的患病率.
- 在这个队列中确定与低维生素D相关的潜在风险因素.
- 调查SCD儿童维生素D水平和临床参数之间的关系.
主要方法:
- 在60名被诊断患有SCD的儿科患者 (3-18岁) 上进行了一项横截面研究.
- 测量血清25-氧维生素D (25-OH-D) 水平,以评估维生素D的状态.
- 使用统计分析,包括逻辑回归和线性回归来确定风险因素.
主要成果:
- 在研究人群中,维生素D缺乏 (25-OH-D < 20 ng/mL) 的患病率为46.7%.
- 年龄 (p=0.002) 和采血季节 (p=0.005) 是与维生素D缺乏相关的重要因素.
- 线性回归显示了维生素D水平与年龄,阳光照射日数和评估季节之间的关联.
结论:
- 低维他命 D 在患有状细胞病的儿科患者中非常普遍.
- 年龄较小,阳光照射减少以及秋冬期间的检测是该人群中维生素D缺乏症的重要风险因素.
- 解决维生素D缺乏症可能对改善SCD儿童的健康结果至关重要.
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