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Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

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Published on: September 26, 2018

更新苏格兰国家心血管风险评分:ASSIGN版本2.0

Paul Welsh¹, Dorien M Kimenai², Mark Woodward^3,4

¹School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK paul.welsh@glasgow.ac.uk.

Heart (British Cardiac Society)

|January 17, 2025

概括

使用苏格兰大学间指南网络 (ASSIGN) 评估心血管风险V.2.0评分的更新,为苏格兰10年动脉样硬化心血管疾病 (ASCVD) 风险提供了更准确的估计. 与最初的ASSIGN分数相比,重新校准改善了模型适合性和风险预测.

科学领域:

心脏病学心脏病学
公共卫生公共卫生
流行病学流行病学

背景情况:

2006年开发的最初使用苏格兰大学间指南网络 (ASSIGN) 评估心血管风险风险评分,估计了10年的动脉样硬化心血管疾病 (ASCVD) 风险.
随着ASCVD率的下降,需要为苏格兰人口提供最新的风险评估工具.

研究的目的:

使用当代数据重新校准ASSIGN风险评分 (V.2.0).
将重新校准与更新ASCVD风险预测的其他方法进行比较.

主要方法:

利用来自英国生物银行和苏格兰一代苏格兰家庭健康研究 (2006-2010) 的苏格兰参与者进行得分推导.
在不居住在苏格兰的英国生物银行参与者中使用外部验证.
测试了重新校准,重新导出和回归调整方法来更新ASSIGN分数.

主要成果:

原来的ASSIGN评分高估了ASCVD风险;重新校准的ASSIGN V.2.0显示了更好的模型适应性.
与观察到的风险相比,ASSIGN V.2.0预测的10年风险中位数较低 (4%的女性,8.9%的男性).
再校准和回归调整产生了类似的改进;重定向提供了适度的收益.

结论:

经过重新校准的ASSIGN V.2.0提供了对苏格兰ASCVD风险的更准确的当代估计.
这一更新的得分将有助于更精确的心血管风险分层和管理.

关键词:

生物标志物生物标志物心血管疾病心血管疾病群组研究群组研究风险评估风险评估风险因素风险因素

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