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Updated: Jun 19, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

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单细胞转录组分析揭示了肝脏巨细胞重编程的特征特征,马洛里-克体的病原发生

Zixuan Fang1,2, Bei Zhong1, Yi Shi1,2

  • 1The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; The Qingyuan Affiliated Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China.

Journal of translational medicine
|January 17, 2025
PubMed
概括

这项研究揭示了慢性肝病中的巨细胞异质性,确定了一种新的脂质相关巨细胞子集. 从受伤的肝细胞中受损的线粒体DNA在马洛里-克体形成过程中激活这些巨细胞中的炎症体.

关键词:
在炎症中,一些细胞会发炎.与脂质相关的巨细胞.马洛里-丹克机构 (MDBs) 是一个.单核RNA序列测序的一个核.我们的mtDNA mtDNA

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Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays08:37

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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...