丁胆酶活性与肝转氨酶之间的关系:一项针对来自秘鲁的农业工人的横截面研究
Emily Ortiz-Delgado1, Guido Bendezu-Quispe2, Fernando Soncco-Llulluy3
1Escuela de Tecnología Médica, Universidad Alas Peruanas, Lima, 150072, Peru.
Journal of occupational medicine and toxicology (London, England)
|January 17, 2025
概括
农业工人接触农药与肝脏损伤有关. 这项研究发现,过氨基酶 (ALT和AST) 的升高与丁基胆酶 (BChE) 抑制有关,这表明它们可以用于监测工人的健康.
科学领域:
- 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 长期接触农药会对神经健康产生不利影响.
- 关于农药诱导的肝损伤和转氨酶活性作为生物标志物的证据有限.
- 对农业化学工人肝脏生物标志物的研究至关重要.
研究的目的:
- 在农业出口工人中,将乙基胆酶 (BChE) 水平与氨酶 (ALT和AST) 活性联系起来.
- 评估转氨酶作为职业环境中农药暴露的潜在生物标志物.
- 了解BChE抑制和肝酶升高之间的关系.
主要方法:
- 采用秘鲁459名农业出口工人的医疗职业记录进行的横截面研究.
- 对人口统计数据,职业史和BChE,ALT和AST的实验室值进行分析.
- 在BCHE抑制和高氨酸酶水平之间的统计学关联.
主要成果:
- 15.3%的工人表现出BCHE抑制,21.6%的工人呈现出高胺酶水平.
- 在BCHE抑制和升高的AST (PR=0.798) 和ALT (PR=0.419) 之间发现了显著的关联.
- 平均BChE,ALT和AST水平分别为6238.8U/l,34.4U/l和22.4U/l. 这两种水平均为6238.8U/l,34.4U/l和22.4U/l.
结论:
- 转氨酶水平显示,农业工人中农药暴露的生物标志物具有潜力.
- 升高的ALT和AST可以作为由于职业农药暴露导致的肝脏组织损伤的指标.
- 建议在农业行业的职业健康计划中监测转氨酶活性.
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