使用新型放射性核素进行定量临床成像试验的PET和SPECT摄像头的验证方法
Dale L Bailey1,2, Kathy P Willowson3,4, Graeme O'Keefe5
1Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia; dale.bailey@sydney.edu.au.
概括
在临床试验中,使用非标准放射性核酸如-124和-131. 一种新的方法对PET和SPECT成像的定量准确性进行校准和验证. 这确保了先进的核医学研究可靠的数据质量保证.
科学领域:
- 核医学就是核医学.
- 医疗成像医学成像
- 放射化学 放射化学是指辐射化学.
背景情况:
- 在临床试验中,定量准确性和质量保证对于正子发射断层扫描 (PET) 和单光子发射计算机断层扫描 (SPECT) 来说至关重要.
- 标准校准协议通常依赖于诸如-18之类的放射性核素,因此对于非标准的放射性核素,特别是那些半衰期较长的放射性核素,需要新的方法.
研究的目的:
- 开发和报告一种用于校准和验证PET和SPECT成像系统的定量准确性和质量保证的方法.
- 在临床成像试验的背景下,调整这些方法以用于非标准放射性核素,特别是具有更长半衰期的放射性核素.
主要方法:
- 实施了三步校准协议:使用标准放射性核素进行验证,在简单的几何结构中测试新型放射性核素,并使用NEMA NU-2 IEC图像质量幻影在复杂的几何结构中进行评估.
- 该方法以-124 (PET) 和-131 (SPECT) 为例,需要使用低剂量CT全身断层成像.
- PET系统的校准涉及对非标准放射性核素进行剂量校准调整,而SPECT校准使用核心实验室的独立灵敏度测量.
主要成果:
- 七个澳大利亚站点成功合格了10台用于-124成像的PET/CT扫描仪和8台用于-131成像的SPECT/CT系统.
- 一个PET/CT系统超过了规定的定量准确度 (SUVavg为1.0 ± 0.05).
- 所有合格的SPECT/CT系统都在真实放射性度的±10%内实现了定量准确性.
结论:
- 在临床试验中成功建立了用于定量成像的PET和SPECT系统校准和验证的可通用方法.
- 开发的程序相对简单,可以由现场工作人员使用临床试验组织提供的设备来实施.
- 这种方法提高了在临床试验中使用更广泛的放射性核素的定量成像数据的可靠性.
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