饮酒障碍和2型糖尿病患者的糖尿病并发症
Sarah Cook1, Sonia Saxena2, Rohini Mathur3
1School of Public Health, Imperial College London, London, United Kingdom sarah.cook@imperial.ac.uk.
BJGP open
|January 17, 2025
概括
患有酒精使用障碍 (AUD) 和2型糖尿病 (T2DM) 的人面临严重糖尿病并发症的风险明显更高. 这项研究强调,与没有AUD患者相比,AUD患者主要不良结果的发生率几乎是AUD患者的两倍.
科学领域:
- 医学研究 医学研究
- 临床流行病学临床流行病学
- 公共卫生 公共卫生
背景情况:
- 患有酒精使用障碍 (AUD) 发展为2型糖尿病 (T2DM) 的人面临糖尿病相关并发症的风险较高.
- 了解这些风险对于有效的患者管理和预防策略至关重要.
研究的目的:
- 为了比较糖尿病并发症的发病率和在英国T2DM诊断前AUD和无AUD患者之间的监测实践.
- 评估AUD对严重结局风险的影响,如末期脏疾病,截肢和死亡率.
主要方法:
- 利用临床实践研究数据链接Aurum,与医院病例统计和ONS死亡率数据联系在一起.
- 使用临床诊断,酒精戒断或慢性酒精相关伤害代码来定义AUD.
- 对HbA1c,肌素和胆固醇的年度监测进行比较,以及T2DM患者中ESRD,下肢截肢,MI,中风,心血管疾病死亡率和全因死亡率的发病率 (2004-2019).
主要成果:
- 该研究包括543,509人,其中15237人 (2.8%) 具有AUD代码.
- 与没有AUD的人相比,患有AUD的人的ESRD (IRR1.95),下肢截肢 (IRR1.78),中风 (IRR1.36),心血管疾病死亡率 (IRR1.74) 和全因死亡率 (IRR2.10) 显着更高.
- 糖尿病监测率高,在各组之间相似 (83.5-92.4%).
结论:
- 患有AUD的个体对大多数研究的糖尿病并发症的发生率大幅增加,几乎使几种不良结果的风险增加了一倍.
- 尽管监测率高,但AUD与糖尿病并发症负担显著增加有关.
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