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代谢学识别了局部辐射损伤的血生物标志物

Lucie Ancel¹, Stéphane Grison², Olivier Gabillot¹

¹Institut de Radioprotection et de Sureté Nucléaire (IRSN), PSE-SANTE/SERAMED/LRAcc, 31 av de la Division Leclerc, Fontenay-aux-Roses, 92260, France.

Scientific reports

|January 17, 2025

概括

早期诊断辐射损伤至关重要. 这项研究在小鼠血中发现了一组6代谢物板,包括普特瑞辛和乌拉,可以准确预测局部皮肤辐射损伤的严重程度和剂量.

科学领域:

生物化学生物化学
毒理学毒理学毒理学
医学诊断医学诊断医学诊断

背景情况:

局部皮肤辐射损伤 (LRI) 呈现出不可预测的炎症反应,使诊断和治疗复杂化.
早期发现LRI对于放射性事故后的有效医疗管理至关重要.

研究的目的:

为了确定循环中的代谢物生物标志物,用于早期诊断和预后LRI.
在临床前模型中建立代谢物水平,损伤严重程度和生理参数之间的相关性.

主要方法:

使用C57BL/6J小鼠模型,在两个队伍中照射后肢.
使用质谱仪对血代谢物进行广谱和可疑查.
应用多块稀疏部分最小平方区分分析 (sPLS-DA) 进行整合性数据分析.

主要成果:

鉴定了与LRI相关的六种代谢物签名 (普特雷辛,乌拉,2,3-二基酸盐,3-基酸盐,L-氨酸,高酸盐).
这个小组有效地根据辐射剂量和损伤严重程度来区分小鼠.
证明了代谢物水平与生物/生理参数 (如损伤严重程度和皮肤 perfusion) 之间的相关性.

结论:

一个特定的血代谢物板作为小鼠LRI的相关分子特征.
循环中的代谢物显示出作为LRI预后和诊断的生物标志物的前景.
这一发现支持开发用于辐射暴露的非侵入性诊断工具.

关键词:

电离辐射辐射的电离辐射.局部辐射伤害局部辐射伤害代谢产物的代谢物分子生物标志物分子生物标志物

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