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相关概念视频

Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

200
Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
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Bioreactor Controls-III01:22

Bioreactor Controls-III

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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
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Designing Growth Media for Bioreactors01:30

Designing Growth Media for Bioreactors

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Growth media provide essential nutrients that support cell growth and metabolism, thereby enhancing the yield of valuable products such as enzymes, antibiotics, and biomass. Designing an effective growth medium involves balancing all components to prevent nutrient limitations or toxic excesses, both of which can impair growth and reduce product yields.Composition of a Typical Growth MediumA typical growth medium contains carbon and nitrogen sources, salts, vitamins, trace elements, and...
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Scale-Up Processes01:14

Scale-Up Processes

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The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
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Upstream Processing01:27

Upstream Processing

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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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开发一个空间生物制造的替代媒介.

Hakyung Lee1, Jinjin Diao2, Yuxin Tian1,3

  • 1Washington University in St. Louis, Saint Louis, MO, USA.

Nature communications
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概括
此摘要是机器生成的。

本研究引入了替代原料驱动的现场生物制造 (AF-ISM),以使太空生物制造具有成本效益. 研究人员使用火星规律石,回收塑料和废物,在微重力条件下生产了烯,相当于地球的生产水平.

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科学领域:

  • 天体生物学 天体生物学
  • 生物技术是生物技术.
  • 材料科学 材料科学 材料科学

背景情况:

  • 长期的人类太空任务需要可持续的,自给自足的生命支持系统.
  • 目前在太空中的生物制造依赖于地球提供的原料,阻碍了经济可行性和可扩展性.
  • 减少对地球补给的依赖对于外星人居住至关重要.

研究的目的:

  • 开发和评估一种替代原料驱动的现场生物制造 (AF-ISM) 工艺.
  • 评估在太空中生物制造新原料的利用情况.
  • 为了确定AF-ISM的经济可行性,以生产像利科这样有价值的化合物.

主要方法:

  • 研究的火星/月球 regolith,回收聚乙烯二甲 (PET) 和便废物作为替代原料 (AF).
  • 使用Rhodococcus jostiiPET菌株S6 (RPET S6) 用于烯的生产.
  • 在模拟的微重力条件下进行实验,并进行经济分析.

主要成果:

  • RPET S6成功地使用了对矿物质的要求的规质模拟剂.
  • 无氧预处理的便废物增强了RPET S6细胞生长.
  • 使用AF在微重力条件下生产烯与以地球为基础的生产相当.
  • 与传统方法相比,AF-ISM显示显著降低了成本.

结论:

  • AF-ISM是一种可行的策略,可以减少对地球原料的依赖,用于太空生物制造.
  • 使用规石,回收PET和废物提供了一个可持续的原料解决方案.
  • 这种方法显著提高了建立自给自足的外星息地的经济可行性.