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Updated: Jun 2, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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TRIM28是三维染色体状态的重要调节者,是CD8+T细胞激活的基础

Kun Wei1, Ruifeng Li1,2, Xiaohong Zhao1

  • 1Institute for Immunology, Tsinghua University, Beijing, 100084, China.

Nature communications
|January 17, 2025
PubMed
概括

该研究显示,TRIM28蛋白通过调节3D基因组组织和基因转录,对CD8+T细胞激活至关重要. 它的缺失会损害T细胞的反应和自身隐性IL-2的产生.

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