在高空暴露后对视网膜和视觉通路电生理学和结构的纵向评估
Xiaoling Shi1,2,3,4, Minglu Li5, Xinjuan Zhang6,7,8
1Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, 361000, Fujian, China.
概括
高空暴露会通过影响视网膜细胞功能,暂时损害视力. 在回到海平面后,视觉功能和眼球 perfusion 逐渐恢复.
科学领域:
- 眼科医生 眼科 眼科
- 航空航天医学 航空航天医学
- 神经科学是一个神经科学.
背景情况:
- 众所周知,高海拔 (HA) 暴露会导致视觉功能受损.
- 了解恢复过程和潜在的视网膜和视觉通路机制至关重要.
研究的目的:
- 从HA返回后动态观察视觉功能.
- 通过检查视网膜和视觉通路的结构和功能来阐明视觉恢复的机制.
主要方法:
- 23名受试者在30天前,1周后,3个月后在4300米处被评估.
- 使用视觉认知 (时钟任务),电生理学 (p-VEP,ff-ERG) 和成像 (OCT,CDI,MRI) 的方法.
- 分析了数据,以将视觉功能变化与结构和生理参数相关联.
主要成果:
- 在HA后一周:反应时间增加,右眼中的 scotopic ERG a-wave和振荡潜力下降.
- 三个月后的HA:降低了scotopica波幅 (右眼),增加了眼动脉速度和眼 perfusion 压力.
- 视觉唤起潜力 (VEP) 和视觉通路结构保持正常;HA影响了杆和圆反应.
结论:
- 高空暴露会损害视网膜的杆状和状反应.
- 在回到海平面后,视觉细胞功能逐渐恢复.
- 恢复与改善的眼球输液相吻合,这表明它在视觉恢复中的作用.
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