大肠直肠癌和中心肥胖症
Fatemeh Safizadeh1,2, Marko Mandic1,2, Michael Hoffmeister1
1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
JAMA network open
|January 17, 2025
概括
腰围 (WC) 和腰与部比率 (WHR) 等中心肥胖指标是比体重指数 (BMI) 更好的结直肠癌 (CRC) 风险指标. 更高的WC和WHR与更高比例的CRC病例有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 结肠直肠癌 (CRC) 的风险与体重过重有关,通常用体重指数 (BMI) 来衡量.
- 中央肥胖指标,如腰围 (WC) 和腰比 (WHR),可以更准确地评估肥胖和CRC风险.
- 人口归因分数 (PAF) 量化了与特定风险因素相关的疾病病例比例.
研究的目的:
- 评估和比较与高中央肥胖指标 (WC和WHR) 相关的结直肠癌 (CRC) 病例的人口归因分数 (PAF) 与高体重指数 (BMI).
主要方法:
- 基于人口的队列研究利用英国生物库,包括458,543名40-69岁的参与者.
- 根据BMI,WC和WHR计算CRC发病率的危险比率 (HRs) 和PAFs.
- 分析考虑了潜在的反向因果关系,排除了最初的随访年.
主要成果:
- 与BMI相比,较高的WC和WHR显示出与CRC发病率的更强的关联.
- 对于CRC的PAFs在高WC (17.3%) 和WHR (17.6%) 时明显高于最初高BMI (9.9%) 的PAFs.
- 在排除了前7年的随访后,PAF变得可比:BMI (15.7%),WC (16.9%) 和WHR (18.0%).
结论:
- 当仅使用身体质量指数 (BMI) 时,归因于超重的结直肠癌 (CRC) 病例的比例被低估了.
- 中央肥胖指标 (WC和WHR) 表明CRC负担较高.
- 针对中心肥胖的公共卫生策略对于CRC预防工作至关重要.
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