碳水化合物和重症烧伤患者的伤口愈合:一个回顾性队列研究
Asia Nakakura1, Beth A Shields1, Leopoldo C Cancio1
1US Army Institute of Surgical Research, JBSA Ft Sam Houston, TX, US.
概括
在烧伤患者中,高碳水化合物营养显著改善了伤口愈合和降低了败血症率. 这种营养策略为严重烧伤恢复提供了临床益处.
科学领域:
- 烧伤危急护理 烧伤危急护理
- 在创伤中提供营养支持.
背景情况:
- 以前的研究表明,高碳水化合物和低脂肪摄入量对急性烧伤患者有好处.
- 在这个燃烧中心的标准实践中,以前使用了高蛋白,低脂肪的肠道配方.
研究的目的:
- 评估一种新的高碳水化合物 (60%) 的肠道养方案对严重烧伤患者的伤口愈合率的影响.
- 评估二次结果,包括真菌感染,缺血性肠道,败血症和死亡率.
主要方法:
- 一项回顾性研究,将高碳水化合物 (POST组) 与以前高蛋白/低脂肪 (PRE组) 养方案进行比较.
- 根据年龄,烧伤大小,深度,吸入伤害和性别,患者与2:1匹配.
- 分析了66名患者 (18%是女性,年龄42±13岁,烧伤大小38±21%TBSA).
主要成果:
- 与PRE组 (0.7%±0.5%TBSA/day) 相比,POST组的伤口愈合率显著提高 (1.1%±0.5%TBSA/day) (p=0.037).与PRE组相比,POST组的伤口愈合率显著提高 (0.7%±0.5%TBSA/day) (p=0.037).
- 败血症的发病率在POST组 (41%) 与PRE组 (70%) (p=0.021) 中明显较低.
- 在缺血性肠道,侵入性真菌伤口感染或死亡率方面没有发现显著差异.
结论:
- 实施高碳水化合物 (60%) 肠道养方案与严重烧伤患者的伤口愈合加速有关.
- 这种营养调整也导致了败血症发病率的显著减少.
- 这些发现支持向更高碳水化合物配方转变,以获得最佳的烧伤患者康复.
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