挑战Astral质量分析仪以前所未有的准确度量化每单细胞多达5300个蛋白质,以揭示细胞异质性

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Updated: Aug 12, 2026

Counting Proteins in Single Cells with Addressable Droplet Microarrays
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Counting Proteins in Single Cells with Addressable Droplet Microarrays

Published on: July 6, 2018

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Julia A Bubis1, Tabiwang N Arrey2, Eugen Damoc2

  • 1Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria. julia.bubis@imp.ac.at.

Nature methods
|January 17, 2025
PubMed
概括

这项研究增强了单细胞蛋白质组学,实现了更大的蛋白质组深度和最小细胞样本的准确量化. 这种新方法可以识别成千上万种蛋白质,从而实现详细的细胞分析和人类胚胎细胞系的分化.

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Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...