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生物制造的3D肠道模型作为药物毒性检测的动物基方法的替代方案

Larissa Bueno Tofani1, Thayná Mendonça Avelino1, Rafael Júnior de Azevedo1

  • 1Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, 13083-100, Brazil.

Tissue engineering and regenerative medicine
|January 17, 2025
PubMed
概括

一个新的3D生物打印肠道模型准确地预测药物反应,改善临床前药物开发和减少动物试验. 这种先进的体外模型增强了对毒性评估的人类反应的预测.

关键词:
在3D生物打印中使用3D生物打印三维细胞培养的3D细胞培养替代动物方法 替代动物方法生物制造的生物制造肠道屏障 肠道屏障 肠道屏障

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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...