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乳腺癌转移中的休眠状态的微环境调节:"改变忠诚的盟友"

Evrim Ceren Kabak^1,2, Sok Lin Foo¹, Maria Rafaeva¹

¹Laboratory of Tumor Heterogeneity, Metastasis and Resistance, Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland.

Advances in experimental medicine and biology

|January 17, 2025

概括

乳腺癌细胞可以进入休眠状态,可能导致复发. 了解瘤微环境的理解

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
癌症转移癌症转移

背景情况:

乳腺癌的缓解通常会在约30%的病例中复发,通常是在细胞休眠期间之后.
细胞癌休眠期涉及扩散瘤细胞 (DTCs) 进入非增殖状态,为治疗干预提供一个窗口,以防止转移性生长.

研究的目的:

为了识别乳腺癌中休眠的DTC.
描述细胞内在和瘤微环境 (TME) 介导的机制,影响转移性器官中的DTC休眠状态.
探索TME驱动器的乳腺癌细胞休眠在遥远的地方.

主要方法:

利用体内模型和体内三维培养系统来研究DTC休眠状态.
研究肺,骨,肝脏和大脑等转移器官中的微环境因素.
在TME中分析来自免疫细胞,树皮细胞和细胞外基质的信号.

主要成果:

在各种转移性器官中,已经确定了多种DTC休眠的微环境驱动因素.
包括免疫细胞,树皮细胞和细胞外基质在内的TME组件介导休眠诱导和持久性.
在TME的变化可以触发休眠DTCs的重新唤醒.

结论:

瘤微环境在维持乳腺癌细胞在遥远器官中的休眠状态方面发挥着至关重要的作用.
了解TME介导机制对于制定针对休眠DTC和预防癌症复发的策略至关重要.
对于休眠向疗法,需要解决翻译性挑战,包括有限的患者样本和临床试验设计.

关键词:

乳腺癌是什么? 乳腺癌是什么扩散的瘤细胞已经扩散.休眠状态是一个休眠状态.转移转移转移转移微观环境是一个微观环境.利基市场是一个利基.静止是一种静止.复发复发的情况

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