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发生率和前列腺特异性抗原持久性和急性前列腺切除术后复发的预后影响:基于人口的研究研究
Pietro Scilipoti1,2, Hans Garmo1, Rolf Gedeborg1
1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Journal of the National Cancer Institute
|January 17, 2025
概括
大约三分之一的男性经历前列腺特异性抗原 (PSA) 持久性或在前列腺癌 (PCa) 手术后10年内复发. 结果因癌症细节和复发时间而异,影响死亡风险.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 前列腺特异性抗原 (PSA) 持续性和前列腺癌 (PCa) 激进前列腺切除术 (RP) 后复发的发生率有所变化.
- 了解这些结果对于手术后的PCa管理至关重要.
研究的目的:
- 为了确定PSA持久性和RP后复发的发生率.
- 调查PSA持久性和PCa患者复发的预后影响.
主要方法:
- 瑞典的一项基于登记的队列研究包括在2007年至2020年期间被诊断患有PCa的男性,他们接受了RP.
- 竞争风险累积发病率曲线被用于估计风险.
- 治疗模式和PCa死亡和其他原因的风险按持久性,复发风险组,复发时间和预期寿命分层.
主要成果:
- 在10700名男性的队列中,RP后PSA持续或复发的10年风险为34%.
- 在持续/复发的12个月内,75%的高风险或早期复发的男性接受了治疗.
- 10年PCa死亡风险在2%至12%之间,而其他原因死亡风险在11%至16%之间.
结论:
- 大约三分之一的男性在RP后10年内经历PSA持久性或复发.
- 前列腺癌 (PCa) 死亡风险因癌症特征和复发时间而有很大差异.
- 存在非PCa死亡的重大风险;这些因素应指导持久性或复发性男性的治疗决策.
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