由光线D-素诱导的肠张张会促进雄性大鼠GLP-1分泌
Shiori Mizuma1, Masaki Hayakawa1, Tohru Hira1,2
1Laboratory of Nutritional Biochemistry, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Endocrinology
|January 17, 2025
概括
通过引起肠道膨胀,D-allulose刺激了类似葡萄糖类-1 (GLP-1) 的分泌. 这种物理机制,而不是新陈代谢,是GLP-1释放的关键驱动因素,为其调节提供了新的见解.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 代谢过程中的代谢.
背景情况:
- 营养素通过细胞内代谢刺激葡萄糖类-1 (GLP-1) 的分泌.
- 作为一种不可代谢的果糖表皮体,D-粉素刺激GLP-1的分泌,但机制尚不清楚.
- 之前的观察表明,在老鼠中,阿卢洛斯的使用与肠道张张和GLP-1分泌量的增加有关.
研究的目的:
- 为了研究由粉和其他因素引起的肠胀是否会刺激大鼠GLP-1分泌.
- 为了阐明素诱导GLP-1分泌背后的机制.
主要方法:
- 通过口服给药Allulose含有或不含有碳酸水.
- 施用难以吸收的物质 (聚乙烯糖1000,D-曼尼托尔) 和一种难以吸收的物质 (纤维素).
- 在肠道内注射空气以诱导肠道膨胀.
- 测量GLP-1分泌和与肠道内容体积和直径的相关性.
主要成果:
- 口服同时服用碳酸水增强了素诱导的GLP-1分泌.
- 难以吸收的物质 (聚乙烯糖1000,D-曼尼托尔) 刺激了GLP-1的分泌,而不溶性物质 (纤维素) 则没有.
- GLP-1的分泌量随着绝对数量的粉素的增加而增加,与肠道含量体积和直径正相关.
- 内空气的使用诱导了GLP-1分泌.
结论:
- 艾卢洛斯促进GLP-1分泌,至少部分通过肠道膨胀.
- 肠道膨胀代表了GLP-1分泌的新机制.
- 肠道的体力刺激可能有助于食后GLP-1分泌.
更多相关视频
09:16Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
Published on: April 20, 2017
15.5K
07:05Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
5.8K
相关概念视频
01:24Glucagon-like Receptor Agonists
295
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
295
01:26Glucose Absorption Into the Small Intestine
31.2K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.2K
01:50What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K