在圆和圆杆变症中进行哈迪-兰德-里特勒彩色视觉测试:与结构和功能结果指标的相关性
Brindhan Tharmarajah1,2, Elisa E Cornish1,2,3, Jonathan Nguyen1,2
1Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Eye (London, England)
|January 17, 2025
概括
哈迪-兰德-里特勒 (Hardy-Rand-Rittler,简称HRR) 彩色视觉测试有效地与形和形-杆缩症患者的视觉功能和视网膜结构相关联. 这种简单的测试有助于监测疾病进展,当电网膜学无法使用时.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 遗传学是一种遗传学.
- 视网膜疾病 视网膜疾病
背景情况:
- 圆和圆杆缩症是影响圆光受体的遗传性视网膜疾病.
- 准确评估疾病进展对于患者管理至关重要.
- 目前的监测通常依赖于电网膜学 (ERG),这可能并不总是可访问的.
研究的目的:
- 评估Hardy-Rand-Rittler (HRR) 彩色视力测试与形和形-形变症患者的已建立的功能和结构评估之间的相关性.
- 确定HRR测试作为疾病进展的替代标记物的有用性.
主要方法:
- 通过ERG诊断的34名形和69名形-形变症患者的回顾性分析.
- HRR彩色视力测试得分与视敏度 (VA),ERG反应,光谱域光学一致性断层扫描 (OCT) 结果和眼底自光检测结果进行了比较.
- 分析了HRR得分与各种功能和结构参数之间的相关性.
主要成果:
- HRR板标识与最佳校正的距离视敏度有显著的相关性 (logMAR VA; r = -0.49, p < 0.0001).
- HRR得分与OCT指标 (圆形区域间隙宽度,斑点厚度),ERG参数 (30 Hz闪,光适应的b波) 和模式ERG幅度 (p50) 有显著的相关性.
结论:
- 哈迪 - 兰德 - 里特勒彩色视觉测试表明,在形和形-杆缩症中,结构和功能测量都具有强烈的相关性.
- HRR测试提供了一种实用的,基于临床的方法来监测这些患者的疾病进展,特别是当ERG无法实现时.
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