在接受白内障手术的患者中诱导了眼睛表面植物的抵抗
Elise Meide1, Tanner Ferguson1,2, Daniel Terveen1,2
1University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
概括
在白内障手术前,手术前的局部莫西弗洛克萨减少了眼睛表面细菌,但没有消除它,并且可能诱导耐药性. 这凸显了局部抗生素的潜在局限性及其对预防内炎的影响.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 白内障手术需要无菌条件,以防止术后感染,如内炎.
- 局部抗生素通常在手术前使用,以减少眼睛表面的细菌负荷.
- 抗生素耐药性的出现是手术预防中日益关注的问题.
研究的目的:
- 为了研究手术前短时间局部用莫西弗洛克萨在减少眼睛表面细菌方面的疗效.
- 为了评估抗生素3天疗程后,眼睛表面细菌中莫西素耐药性的发展.
- 评估手术前局部抗生素对白内障手术前细菌生长和耐药性的影响.
主要方法:
- 采用了前性,双臂,随机化研究设计.
- 研究小组 (17名患者) 在手术前的三天内每天四次接受莫西素.
- 对照组 (11名患者) 没有接受手术前的局部抗生素.
- 在手术前和手术当天早上采集了眼睛表面的拭子.
主要成果:
- 在手术的上午,moxifloxacin组的52%的患者有眼睛表面细菌生长,而对照组的100% (p=0.0097).
- 在研究之前,没有患者表现出抗莫西素的细菌.
- 在手术的上午,moxifloxacin组中有17%的细菌产生了对moxifloxacin的耐药性,对照组则为0% (p=0.2579).
结论:
- 短期的手术前局部抗生素可以减少但不能消除眼睛表面的细菌.
- 在手术前使用抗生素可能会诱导细菌耐药性,可能会损害未来的抗生素疗效.
- 这些发现表明,局部抗生素可能比室内抗生素在预防和治疗内耳炎方面效果不佳.
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