对Lentinus多彩的治疗性审查,注意其抗氧化,抗微生物和抗癌属性
Arghya Naskar1, Rituparna Saha1, Gouri Basak1
1Molecular and Applied Mycology and Plant Pathology Laboratory, Centre of Advanced Study, Department of Botany, University of Calcutta, Kolkata, 700019, West Bengal, India.
Applied biochemistry and biotechnology
|January 17, 2025
概括
这项研究验证了Lentinus polychrous,一种未被充分利用的,揭示了重要的抗氧化和抗菌特性. 它还通过诱导亡,对肺癌细胞产生强大的抗癌作用,突出显示了其治疗潜力.
科学领域:
- 菌类学 菌类学是指菌类学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 是一种有价值的治疗化合物的来源,具有传统使用历史.
- 自然产品在现代药物的发展中起着至关重要的作用.
- (Lentinus polychrous) 是一种未被充分利用的,在印度西孟加拉邦发现.
研究的目的:
- 为了从分类学上验证Lentinus多色.
- 分析其二次代谢概况.
- 评估其对抗氧化应激,微生物耐药性和癌症的潜力.
主要方法:
- 在体外分析甲醇提取物.
- 使用有效度 (EC50) 确定抗氧化剂活性.
- 对抗人类致病细菌的抗菌功效的评估 (MIC50).
- 对A549肺癌细胞 (LD50) 和诱导亡的抗癌性质的评估.
主要成果:
- 提取物表现出广泛的抗氧化活性 (EC50: 403.6 ± 3.8 至 841.2 ± 10.7 微克/毫升).
- 它对致病细菌 (MIC50: 302.2 ± 3.8 到 570.6 ± 1.8 微克/毫升) 显示出有效性,可能是通过破坏细菌细胞壁.
- 观察到针对A549细胞的抗癌活性 (LD50: 120.9 ± 1.83 μg/mL),通过通过Bcl-2家族基因表达调节来诱导亡.
结论:
- 兰丁多色具有显著的抗氧化和抗菌特性.
- 提取物对肺癌细胞具有显著的细胞毒性作用.
- 这些发现强调了Lentinus多色的潜力,用于开发新的治疗药物.
关键词:
抗菌剂 抗菌剂 抗菌剂细胞灭亡 (apoptosis) 是一种死亡的过程.Bcl-2 的使用方法.化疗 化疗是一种化学疗法.药用是一种药用.氧化应激是一种氧化应激.扫描电子显微镜扫描电子显微镜更多相关视频
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