改变了厌食症神经性妇女的感觉运动状状网络连接
Yu-Ping Wang1, Min-Yi Chu1, Yi Wang2,3
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
概括
神经性厌食症 (AN) 患者表现出变化的条状功能连接,特别是与感觉运动和视觉区域的连接减少,这可能是疾病特异性的. 即使控制体重不足时,这些变化仍然存在.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 神经性厌食症 (AN) 涉及到奖励处理,认知控制和身体形象障碍,表明条纹功能障碍.
- 低体重可能会影响大脑功能,需要对其急性影响进行控制.
研究的目的:
- 调查全脑静止状态功能连接 (rsFC) 的状体在AN患者.
- 区分AN相关的rsFC变化与体重不足的影响.
主要方法:
- 在AN患者 (n=39),正常体重健康对照组 (NHC,n=31) 和体重不足健康对照组 (UHC,n=22) 中比较了条状RSFC.
- 利用理论上选择的条纹性子区域进行全脑rsFC分析.
- 在AN患者中进行了rsFC和临床测量之间的相关性分析.
主要成果:
- 与NHC相比,AN患者表现出与前端-双侧网络 (FPN) 带状RSFC增加.
- 与NHC和UHC相比,AN患者的感觉运动和视觉区域的条纹性rsFC减少.
- 在AN患者的条状RSFC和临床变量之间没有发现显著的相关性.
结论:
- 带状RSFC与感觉运动和视觉区域的减少可能代表AN中的疾病特异的神经相关物.
- 这些发现突出了AN的潜在神经标志物,独立于急性体重不足的影响.
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