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不同的肥胖指标与 inguinal 的风险之间的关联

Hekai Shi¹, Xiaoyu Peng¹, Yiming Lin¹

¹Department of General Surgery, Huadong Hospital, Fudan University, No. 221, West Yan'an Road, Jing'an District, Shanghai, 200040, People's Republic of China.

Updates in surgery

|January 17, 2025

概括

通过体重指数和腰围来衡量的肥胖与较低的 inguinal hernia 风险有因果关系. 这种关联显示了种族差异,突出了脂肪分布在发育中的作用.

科学领域:

遗传学和流行病学
代谢健康和疾病
手术风险因素手术风险因素

背景情况:

肥胖是众所周知的各种健康状况的风险因素.
肥胖和 inguinal hernia 风险之间的关系已经确立,但需要对特定的肥胖指标进行澄清.
了解这种关联对于公共卫生和临床实践至关重要.

研究的目的:

调查各种肥胖指标与 inguinal 风险之间的因果关系.
探索肥胖和 inguinal 之间的关系中的潜在种族差异.
为了区分易于获取和难以测量的肥胖指标的影响.

主要方法:

使用孟德尔随机化 (MR) 分析来评估因果关系.
将肥胖指标分类为易于获得的 (BMI,WC,HC,WHR),中度难以获得的 (体脂百分比,体脂质量) 和难以获得的 (VAT,SAT) 措施.
分析了来自欧洲祖先 (FinnGen队列) 和东亚 (日本生物库) 种群的数据.

主要成果:

对于欧洲祖先,增加的BMI,WC,HC,体脂百分比和体脂质量与较低的 inguinal 的风险有关.
在调整BMI (OR:0.52) 后,腰围仍然与 inguinal hernia 风险的降低显著相关.
在东亚人中,只有身体脂肪质量显示出因果关系与 inguinal 的风险降低,与 BMI,WC 和 HC 不同.

结论:

肥胖与 inguinal 的风险降低有因果关系.
具体的肥胖指标与 inguinal hernia 风险之间的关联表现出种族特异性.
这些发现为脂肪分布和 inguinal 风险之间的关系提供了遗传层面的见解.

关键词:

内 Hernia 是一个内.测量方法测量方法门德尔的随机化肥胖问题肥胖问题

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