在烧伤后加速表观遗传衰老
Jack Sullivan1,2,3, Thomas Nicholson4,5, Jon Hazeldine4,6,7
1Inflammation and Ageing, University of Birmingham, Birmingham, UK. j.sullivan.2@bham.ac.uk.
GeroScience
|January 17, 2025
概括
严重的烧伤会加速生物衰老,增加与年龄相关的疾病的风险. 这项研究发现,燃烧后表观遗传年龄显著加速,特别是在衰老的节奏和PCGrimAge,这表明与增加的发病率有联系.
科学领域:
- 生物医学科学 生物医学科学
- 遗传学 是一个遗传学.
- 老年学是一门学科.
背景情况:
- 严重的烧伤伤害增加了早期与年龄相关的疾病的风险和幸存者的死亡率.
- 烧伤加速生物衰老过程的假设需要进行调查.
研究的目的:
- 用表观遗传时钟研究重大烧伤对生物衰老的影响.
- 为了确定烧伤伤害是否加速成人患者的表观遗传衰老.
主要方法:
- 对来自烧伤患者和健康对照者的外周血液单核细胞进行了DNA甲基化分析.
- 使用表观遗传钟 (PhenoAge,PCGrimAge,Dunedin PACE,Horvath,Hannum) 来计算生物年龄和年龄加速.
- 参与者包括53名烧伤患者 (入院和6个月的随访) 和29名健康对照.
主要成果:
- 在入院时观察到表观遗传年龄加速,PhenoAge显示+7.2年,PCGrimAge显示+9.23年.
- 与对照人群相比,老化PACE在入院时高出31.65%,在受伤后6个月时高出11.36%.
- 在受伤后的6个月内,PCGrimAge仍然显著上升,而PhenoAge则恢复正常. 霍瓦特和汉努姆的时钟没有显著差异.
结论:
- 成年人的烧伤损伤加速表观遗传衰老,特别是衰老的节奏和PCGrimAge.
- 这种加速表明疾病风险增加,这可能解释了在烧伤幸存者中观察到的较高发病率和死亡率.
- 虽然一些表观遗传衰老标志物在6个月后正常化,但其他标志物会持续存在,这凸显了严重烧伤的长期生物影响.
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