在患有三相21的马赛克主义者中内化精神病症状
Ruth C Brown1, Allison D'Aguilar1, Quinn Hurshman2
1Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
概括
患有马赛克唐氏综合征 (mDS) 的个人经历了高水平的抑郁和焦虑. 常规评估对于他们的护理和纳入研究至关重要.
科学领域:
- 遗传学 是一个遗传学.
- 心理学 心理学 心理学
- 发展生物学 发展生物学
背景情况:
- 马赛克唐氏综合征 (mDS) 与非马赛克唐氏综合征相比,表现出不同的症状严重程度.
- 对于mDS的行为表型,其特征仍然不足,特别是在内化症状方面.
研究的目的:
- 调查患有mDS的个体中抑郁和焦虑症状的患病率.
- 探索这些症状与细胞中21型三形的百分比之间的关联.
- 评估MDS个体参与自我报告和护理人员报告研究的可行性.
主要方法:
- 一个由62名患有mDS的参与者 (年龄在12-46岁) 的样本完成了自我报告和照顾者报告措施.
- 使用统计分析,包括MANCOVA和单变量测试,来检查症状流行率和相关性.
- 血液和/或口腔粘膜细胞中的三形21百分比与报告的症状相关.
主要成果:
- 在整体上 (p=0.038) 观察到三症对内部化量表有显著的影响,对年龄和性别进行控制.
- 最初的发现表明三症和恐惧之间存在联系 (p=0.049),但在多次比较纠正后,这并没有保持显著.
- 在三症百分比和特定症状之间没有发现其他显著的关联.
结论:
- 患有mDS的个人表现出高度发生的抑郁和焦虑症状.
- 建议定期对这些心理健康状况进行查,以确保对mDS患者的最佳护理.
- 该研究证实,患有mDS的个体可以有效地参与研究评估,支持将其纳入未来的研究.
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