与抗血栓性药物相关的治疗错误报告给美国中毒中心
Emma N Cravo1,2, Hannah L Hays1,3,4, Jaahnavi Badeti1
1Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
American journal of hematology
|January 17, 2025
概括
从2000年到2021年,涉及抗血栓药物的治疗错误增加了590.9%,老年人和女性受到影响最大. 增加预防工作至关重要,以减少这些药物错误.
科学领域:
- 药物监督 药物监督 药物监督
- 药物安全 药物安全
- 公共卫生 公共卫生
背景情况:
- 抗血栓药物的治疗错误是一个重大的公共卫生问题.
- 了解这些错误的趋势和特征对于开发有针对性的干预措施至关重要.
研究的目的:
- 调查与非医疗保健环境中的抗血栓药物相关的治疗错误的特征和趋势.
- 分析2000年至2021年向美国中毒中心报告的数据.
主要方法:
- 对2000年至2021年国家毒物数据系统 (NPDS) 数据的分析.
- 包括涉及抗血栓药物作为主要物质的治疗错误相关暴露.
- 对错误率,患者人口统计,药物类型和结果的统计分析.
主要成果:
- 报告总共有57,288次治疗错误暴露,在22年内错误率增加了590.9%.
- 大多数错误 (90.1%) 在临床上无关紧要,但2.1%导致严重的医疗结果,包括16例死亡.
- 华法林是最常见的药物,而直接口服抗凝剂 (DOAC) 在2011-2021年期间显示出错误的显著增加. 最常见的错误情景是无意中双倍剂量 (56.3%).
结论:
- 涉及抗血栓药物的治疗错误显著增加,特别是在DOACs,需要加强降低风险的策略.
- 与DOAC相比,与华法林相关的错误更有可能导致严重的结果.
- 需要有针对性的干预措施来防止药物错误,特别是在老年人群中.
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