易于获得和解决方案稳定的Ni(0) 预催化剂用于高通量实验
Gilian T Thomas1, Odhran D Cruise1, Daelin Peel-Smith1
1Department of Chemistry, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5 C2, Canada.
Chemistry (Weinheim an der Bergstrasse, Germany)
|January 17, 2025
概括
新的N,N'-diaryl diazabutadiene (DAB) Ni(0) 复合物为苏苏基和C-N合反应提供稳定,可溶性的催化剂. 这些复合体的高通量实验 (HTE) 性能与Ni ((COD) 2.2) 相当或优于Ni ((COD) 2.2).
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 合成化学 合成化学
背景情况:
- 复合物是交叉合反应中的关键催化剂.
- 开发稳定和可溶性预催化剂对于高效的催化过程至关重要.
- 高通量实验 (HTE) 加快了催化剂选和优化.
研究的目的:
- 为了合成和表征新型N,N'-二二甲 (DAB) Ni(0) 复合物.
- 用HTE评估这些Ni(0) 复合物的基和C-N合反应中的催化性能.
- 为了比较新的Ni(0) 前催化剂与既定的Ni(COD) 2标准的有效性.
主要方法:
- 合成由基联体稳定的N,N'-二二甲 (DAB) Ni(0) 复合物.
- 合成的Ni(0) 复合物的表征.
- 高通量实验 (HTE) 的应用用于催化剂选.
- 在子和C-N合反应中对催化活性的评估.
主要成果:
- 合成的Ni(0) 复合物在各种有机溶剂中具有良好的溶解性和稳定性.
- 这些DAB Ni(0) 复合体在子和C-N合反应中表现出色.
- 发现催化活性与基准Ni ((COD) 2催化剂相等或更好.
- 这些复合物适用于HTE的现场催化剂形成.
结论:
- N,N'-diaryl diazabutadiene (DAB) Ni(0) 复合物代表了一个有前途的前催化剂类.
- 这些复合物在稳定性,溶解性和催化效率方面具有优势.
- 它们适合HTE促进了对交叉合反应的快速催化剂发现和优化.
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