第四期胃癌转化疗法:来自KINGCA WEEK 2024专家共识会议的报告
Tae-Han Kim1, Ichiro Uyama2, Sun Young Rha3
1Department of Surgery, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Journal of gastric cancer
|January 17, 2025
概括
转化疗法,从缓解性转变为治疗性手术治疗第四阶段胃癌,在选定的患者中显示出生存益处. 专家建议个性化治疗和进一步的随机试验以获得证据.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道癌症研究研究
背景情况:
- 第四期胃癌 (GC) 传统上接受了息性全身疗法.
- 转化疗法代表了向治疗性手术治疗的范式转变,用于选择高级GC患者.
研究的目的:
- 建立关于第四阶段GC转化疗法的临床陈述的共识.
- 引导专家对转换疗法的应用,时间和外科手术方法的意见.
主要方法:
- 德尔菲方法与来自韩国胃癌协会 (KINGCA) 的17名专家一起使用.
- 关于转换疗法的9个临床陈述被制定和评估以达成共识.
- 在KINGCA WEEK 2024期间收集和讨论了专家意见.
主要成果:
- 88.3%的专家同意转化疗法改善了实现R0切除的响应者的生存率.
- 94.2%的人认为,转移有限的患者是合适的候选人.
- 推个性化治疗方案 (100%) 和至少6个月的持续时间 (88.3%).
结论:
- 转化疗法为精心挑选的IV期GC患者提供了生存益处.
- 最少侵入性手术和D2淋巴结解剖是最受欢迎的手术方法.
- 大规模的随机对照试验对于验证转化疗法的有效性和安全性至关重要.
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