丁甲通过抑制TRPM8表达来降低慢性鼻炎的炎症反应
Yi Cai1, Mingjian Xie1, Zhoumu Fang1
1Department of Otolaryngology-Head and Neck Surgery, Jinhua People's Hospital Jinhua 321000, Zhejiang, China.
American journal of translational research
|January 17, 2025
概括
丁甲 (CA) 降低了人类鼻腔细胞和慢性鼻炎 (CRS) 的小鼠模型中的炎症和短暂受体潜力 melastatin 8 (TRPM8) 表达. 这表明CA可能会缓解CRS症状.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 是一种常见的鼻通道炎症状况.
- 暂时受体潜力梅拉斯8 (TRPM8) 和促炎性细胞因子 (IL-25,IL-33,TSLP) 参与了CRS的发病.
- 丁甲 (CA) 是一种具有潜在抗炎功能的天然化合物.
研究的目的:
- 为了研究肉甲 (CA) 对人类鼻上皮细胞 (HNECs) 短暂受体潜在拉斯8 (TRPM8) 表达的作用.
- 在慢性鼻炎 (CRS) 的小鼠模型中评估CA的治疗潜力.
主要方法:
- 用CA对待HNEC,并测量了促炎细胞因子 (IL-25,IL-33,TSLP) 和TRPM8的水平.
- 通过卵蛋白 (OVA) 诱导建立了CRS的小鼠模型.
- 用CA治疗小鼠,并评估结果,包括症状频率,鼻炎,细胞因子水平和TRPM8表达.
主要成果:
- 在HNEC中,CA治疗显著降低了促炎性细胞因子和TRPM8表达.
- 与对照组相比,接受CA治疗的小鼠表现出减少了打喷和鼻子.
- 组织学分析显示,CA治疗小鼠的鼻粘膜炎症降低,以及较低的炎症性细胞因子和TRPM8水平.
结论:
- 丁甲有效降低HNEC中TRPM8表达和促炎细胞因子的调节.
- 在小鼠模型中,CA在缓解CRS症状和炎症方面显示出显著的治疗效果.
- 作为治疗慢性鼻炎的潜在治疗剂,CA具有前景.
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