肺癌胸腔镜手术后出现慢性术后疼痛的危险因素
Bin Chen1, Guozhen Shi2, Pengfei Gao1
1Cardio-Thoracic Surgery, Jiangnan University Medical Center Wuxi 214000, Jiangsu, China.
American journal of translational research
|January 17, 2025
概括
年龄,TNM晚期,早期术后疼痛和疼痛恐惧预测肺癌手术后的慢性术后疼痛 (CPSP). 识别这些风险因素可以改善患者的治疗结果,并减少CPSP的发生率.
科学领域:
- 胸部外科手术 胸部外科手术
- 在瘤学瘤学.
- 疼痛医学 医学 疼痛医学
背景情况:
- 慢性术后疼痛 (CPSP) 是胸腔镜肺癌手术后的一个重要并发症.
- 确定CPSP的预测标志物对于有效的患者管理和改善结果至关重要.
研究的目的:
- 为了确定CPSP在非小细胞肺癌 (NSCLC) 胸腔镜激素切除后的独立预测因子.
- 开发和验证CPSP在NSCLC患者中的预测模型.
主要方法:
- 一项回顾性病例控制研究分析了接受胸腔镜手术的106名NSCLC患者的数据.
- 使用后勤回归和ROC曲线分析来识别和验证CPSP预测因素.
- 用20名患者的外部验证队列来确认该模型的性能.
主要成果:
- 晚年,更高的TNM阶段,提升的早期术后疼痛评分,以及增加的疼痛恐惧 (FPQ-III) 是CPSP的显著预测因素.
- 一个预测性名谱显示出优异的歧视 (AUC = 0.891),外部验证为AUC = 0.956.
- 该模型在预测CPSP时显示出高灵敏度 (1.00) 和特异性 (0.923).
结论:
- 年龄,TNM阶段,早期术后疼痛和对疼痛的恐惧是胸腔镜肺癌手术后CPSP的关键预测因素.
- 将这些因素整合到预测模型中可以提高术后护理,并可能降低CPSP率.
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