在塞拉扬医院多次输血肝胆病患者的红细胞合免疫
Prasanthini Nahendran1, Siti Balkis Budin2, Nur Zakiah Mohd Saat3
1Centre for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Asian journal of transfusion science
|January 17, 2025
概括
接受输血的肝胆道患者有高风险发展红细胞合免疫,特别是女性. 输血增加显著与非免疫接种风险相关,强调输血前的免疫血液学测试.
科学领域:
- 输血医学 输血医学
- 免疫血液学 免疫血液学
- 肝胆病管理 肝胆病管理
背景情况:
- 输血支持对于肝胆道疾病患者至关重要.
- 重复输血增加了对免疫的风险,可能会使血液交叉匹配复杂化.
研究的目的:
- 在肝胆病患者中确定红细胞 (RBC) 与免疫接种的发生率.
- 评估抗体发育和人口因素之间的关联.
主要方法:
- 132名肝胆病患者的横截面研究 (2021年2月至9月).
- 进行了ABO血液分组,抗体查,鉴定和交叉匹配.
- 通过二进制后勤回归来评估RBC的免疫和人口因素.
主要成果:
- 观察到高的免疫发病率 (67.4%).
- 最常见的抗体是:抗E (37.6%),抗Mia (14.4%),抗c (12.8%),抗Kidd (11.2%).
- Rh 系统抗体占主导地位 (58.4%);女性的同免疫率更高 (69.8%).
结论:
- 在肝胆病患者中,常见的是红细胞合免疫,有输血并发症的风险.
- 输血包装细胞的数量与免疫接种风险有显著联系.
- 强调了对输血前免疫血液学检测的极大需要.
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