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在"O"血型献血者中,ABO 单聚氨酸标位

Sadhana Mangwana¹, Shashi Kumar¹, Vivek Gangwar¹

¹Department of Transfusion Medicine, Sri Balaji Action Medical Institute, New Delhi, India.

Asian journal of transfusion science

|January 17, 2025

概括

大多数O组献血者具有较低的抗A和抗B抗体标位. 确定关键标位对于输血和移植决策至关重要,以防止溶血反应.

科学领域:

输血医学输血医学
免疫学免疫学免疫学
血液银行血液银行

背景情况:

高抗A和抗B抗体标位与新生儿的血液溶解输血反应和ABO血液溶解疾病有关.
对于输血或移植决策的关键 ABO 抗体标位没有确立的共识.
实施ABO标位测量可能会减少非O组接受者的输血反应.

研究的目的:

调查O组献血者抗A和抗B抗体标位的患病率和水平.
建立在特定地理区域内对 ABO 抗体标位的基线理解.

主要方法:

一项前性研究涉及218名O组献血者在COVID-19大流行期间.
测量免疫球蛋白 (Ig) M和IgG抗体标位,使用凝血和固态红细胞粘附测试.
定义高标位为IgG≥128和IgM≥64;使用Epi Info 7.1.1.进行的统计分析.

主要成果:

研究人口包括96.75%的男性,平均年龄为33.16±8.8岁.
低IgG标位 (<128) 的患病率为抗A的79.36%和抗B的86.24%;低IgM标位 (<64) 的88.53%.
在20.64%的捐赠者中发现高IgG抗A标位,在13.76%的捐赠者中发现抗B标位;没有接受者经历过溶血反应.

结论:

大多数O组的捐赠者表现出低的异凝聚素标位.
确定关键标位值可以帮助制定对ABO不兼容输血和移植的机构指导方针.
自动化的ABO标位测试提供了精度,可重现性和效率,特别是在资源有限的环境中.

关键词:

ABO标位 ABO标位 ABO标位组 O 献血者献血者胎儿和新生儿的血液溶解性疾病免疫球蛋白G抗体标位免疫球蛋白G抗体标位免疫球蛋白M抗体标位免疫球蛋白M抗体标位异凝聚素标位是异凝聚素的标位.

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